The Pharmaceutical Cold Chain

The Pharmaceutical Cold Chain

Research & Development

Discovery labs maintain ultra-cold storage for biologics and cell therapies

Manufacturing

GMP facilities produce vaccines, biologics & temperature-sensitive drugs

Distribution Centers

Regional hubs with monitored cold rooms & automated inventory systems

Pharmacy & Clinics

Local storage with precise temperature logging & compliance

Patient Delivery

Last-mile delivery with insulated packaging to hospitals & homes

$17.2B
Global cold chain pharma market by 2027
25%
Vaccines damaged due to cold chain failures
80%
Biologics require temperature control

Our Mission
RNA, protein, and cell-based therapy distribution is limited by access to the "cold chain" - the infrastructure to keep these fragile medicines cold as they travel across the world to the people who need them. This necessity creates barriers for life-saving therapies in resource-limited and geographically-isolated regions. At Cyternity, we're using nature's lessons to change that.   

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Cyternity Logo
YTERNITY
Life stabilized: Technologies to enable cell-based therapeutics
Anhydrobiosis: Nature's Blueprint for Preservation
Biomimetic Preservation Technology

Anhydrobiosis: Nature's Blueprint for Stability

Nature provides remarkable solutions for long-term biological stability under extreme conditions. Our research harnesses the principles of anhydrobiosis to enable room-temperature preservation of living cells.

Anhydrobiosis
"Life without water" — the ability to survive complete desiccation through specialized molecular mechanisms

Organisms That Master Desiccation

These organisms can endure complete water loss for extended periods, then rehydrate and resume normal function—capabilities not found in any mammalian cell types.

🍄

Fungi

Spores survive decades of desiccation

🌿

Resurrection Plants

Recover from <5% water content

🪱

Nematodes

Anhydrobiotic coiling response

🐻

Tardigrades

Tun state survival for 30+ years

🦟

Insect Larvae

Chironomid larvae tolerate full drying

Critical Cellular Targets for Dry Storage

Successful anhydrobiotic preservation requires protecting multiple cellular structures simultaneously.

Cell Membrane

Lipid bilayer integrity

Proteins

Structure & function

Mitochondria

Energy production

DNA

Genetic integrity

RNA

Transcriptome stability

Therapeutic Applications

Cell-Based

Stem Cells & T-Cells

Vaccines

mRNA & Viral Vector

Biologics

Antibodies & Enzymes

Blood Products

Platelets & Plasma

Current Limitations

-80°C / LN₂

Required for long-term cell storage

Viability loss over time
Limited access
Complex logistics & high cost

Our Goal

Room Temp

Extended dry storage preservation

High cell viability maintained
Full differentiation potential
Global accessibility

Cyternity's Origins
Cyternity is founded on the seminal scientific research pioneered at Biomatrica, the former world leader in the biopreservation of nucleic acids, proteins, and diagnostic assays. Biomatrica’s technology platform established industry standards for stabilizing sensitive biological materials without refrigeration. After the company’s acquisition by Exact Sciences in 2018, its dry-state stabilization products—along with the advanced research and development portfolio—were divested and returned to the original founders.

This portfolio includes cutting-edge work in dry-state preservation of live bacterial and eukaryotic cells, representing a major leap beyond legacy stabilization methods. Cyternity will apply this foundational science toward new commercial applications in high-growth markets.

To execute this vision, Cyternity has assembled an A-class research, development, and commercial team focused on transforming advanced biopreservation science into globally scalable products - medicines for anywhere and everywhere.